Surface salt bridges modulate the DNA site size of bacterial histone-like HU proteins

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Surface salt bridges modulate the DNA site size of bacterial histone-like HU proteins.

Bacterial histone-like DNA-binding proteins are best known for their role in compacting the genomic DNA. Of these proteins, HU is ubiquitous and highly conserved across the eubacterial kingdom. Using the HBsu (Bacillus subtilis-encoded HU homologue) as a model, we explore here the molecular basis for the ability of some HU homologues to engage a longer approx. 35 bp DNA site as opposed to the m...

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The histone-like proteins (HU) belong to a family of DNA architectural proteins that stabilize nucleoprotein complexes. We found a putative HU protein (TgGlmHMM_3045) in Toxoplasma gondii genome that was homologous to the bacterial HU protein. This putative sequence was located in the scaffold TGG_995361 of the chromosome 10. The sequence included the prokaryotic bacterial histone-like domain, ...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 2005

ISSN: 0264-6021,1470-8728

DOI: 10.1042/bj20050274